Bee Venom and Parkinson disease
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More than 500,000 Americans live with Parkinson's, according
to the National Institutes of Health. Each year, 50,000 new
cases are diagnosed. Medications can treat the symptoms,
but none have been shown to slow the progression of the
In 1960, researchers discovered that Parkinson's symptoms were caused by the loss of the neurotransmitter dopamine through the deterioration of the substantia nigra, a small black oblong group of cells at the base of the brain.
According to a recently published study from Germany, "Parkinson's disease(PD) is a neurodegenerative disorder characterized by progressive loss of dopaminergic (DA) neurons of the substantia nigra pars compacta…
"Caffeic acid phenethyl ester (CAPE), an antioxidant flavanoid, has antiviral, anti-inflammatory, antioxidant, and immunomodulatory properties. Recent studies have shown that CAPE has also a neuroprotective effects in ischemia and low potassium-induced neuronal apoptotic models," the authors said…
The researchers concluded, "Since a mitochondrial insult is a major cause for the degeneration of nigral neurons in PD, we hypothesize that propolis derivatives, in particular CAPE, may have a neuroprotective effect on those cells and may be a promising drug candidate to be taken into in vivo models of PD."
Noelker and colleagues published their study in Neuroscience Letters (The flavanoide caffeic acid phenethyl ester blocks 6-hydroxydopamine-induced neurotoxicity. Neurosci Lett, 2005;383(1-2):39-43).
For more information, contact R. Dodel, University of Bonn, Dept. Neurology, Sigmund Freudstr 25, D-53105 Bonn, Germany.
Modern biochemical analytical procedures have been used to identify 18 different components. There is measurable amount of the neurotransmitter Dopamine.